Large company small molecule share of Phase I clinical trial starts vs Antibody-drug conjugate trial starts

In 2025, large company small molecule share of Phase I clinical trial starts worldwide was 66%; antibody-drug conjugate trial starts was 349.

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Global, annual figures, spaced by time from 2022 to 2025 . Different units, drawn on separate scales and clipped to the years both series publish; earlier history stays on each indicator’s own page. Read the values, not the heights.

Large company small molecule share of Phase I clinical trial starts

Unit: % · 2 observations

Line chart
Large company small molecule share of Phase I clinical trial startsLarge company small molecule share of Phase I clinical trial starts. 2 observations from 2022 to 2025, ranging from 61% to 66%. Latest value 66% (2025). % 0 20 40 60 80 2022 2023 2024 2025 61% 66%
Large company small molecule share of Phase I clinical trial startsLarge company small molecule share of Phase I clinical trial starts. 2 observations from 2022 to 2025, ranging from 61% to 66%. Latest value 66% (2025). % 0 20 40 60 80 2022 2023 2024 2025 61% 66%
Large company small molecule share of Phase I clinical trial startsLarge company small molecule share of Phase I clinical trial starts. 2 observations from 2022 to 2025, ranging from 61% to 66%. Latest value 66% (2025). % 0 20 40 60 80 2022 2023 2024 2025 61% 66%
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Large company small molecule share of Phase I clinical trial starts
Period Type Value
2022 Actual 61%
2025 Actual 66%
Source: IQVIA · CC BY 4.0 · Full series

Antibody-drug conjugate trial starts

Unit: count · 4 observations

Line chart
Antibody-drug conjugate trial startsAntibody-drug conjugate trial starts. 4 observations from 2022 to 2025, ranging from 176 to 349. Latest value 349 (2025). 0 100 200 300 400 2022 2023 2024 2025 176 349
Antibody-drug conjugate trial startsAntibody-drug conjugate trial starts. 4 observations from 2022 to 2025, ranging from 176 to 349. Latest value 349 (2025). 0 100 200 300 400 2022 2023 2024 2025 176 349
Antibody-drug conjugate trial startsAntibody-drug conjugate trial starts. 4 observations from 2022 to 2025, ranging from 176 to 349. Latest value 349 (2025). 0 100 200 300 400 2022 2023 2024 2025 176 349
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Antibody-drug conjugate trial starts
Period Type Value
2022 Actual 176
2023 Actual 233
2024 Actual 282
2025 Actual 349
Source: ClinicalTrials.gov · CC BY 4.0 · Full series

Shared periods

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2 periods are published for both series as annual figures on the same basis. Comparing anything else would mean comparing different periods.

Period Large company small molecule share of Phase I clinical trial starts Antibody-drug conjugate trial starts
2022 61% IQVIA 176 ClinicalTrials.gov
2025 66% IQVIA 349 ClinicalTrials.gov

Provenance

Where these numbers come from

Large company small molecule share of Phase I clinical trial starts

Percentage of Phase I clinical trial starts sponsored by large pharmaceutical companies that investigate small molecule drugs.

2 observations charted in Global · source organisations: IQVIA

Antibody-drug conjugate trial starts

Count of interventional studies whose record mentions an antibody-drug conjugate by class or by payload/brand stem (deruxtecan, vedotin, govitecan, emtansine, tirumotecan, rezetecan and others) whose start date falls in the period. The region is a site country: a study counts for every country where it lists a site, so regional counts overlap and do not sum to the global count.

4 observations charted in Global (of 6 annual records) · source organisations: ClinicalTrials.gov

Data published under CC BY 4.0. Series A as JSON · Series B as JSON

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